Carbon Nanotubes for Drug Delivery Review

Carbon Nanotubes for Drug Delivery Review Using the functionalized carbon nanotubes and other nanomaterials to deliver the antimicrobial drugs, is one of the most applications of carbon nanotubes. Several studies were conducted about this topic. Amphotericin B (AMB) is one of the first antimicrobials to be delivered with CNTs. Wei Wu et al. studied the Targeted Delivery of Amphotericin B to Cells by using Functionalized Carbon Nanotubes, they used oxidized MWCNTs that were functionalized with AMB and FITC. They found that at equivalent AMB concentration of 10  µg/mL, this CNT conjugate was found to be significantly less cytotoxic to Human Jurkat lymphoma T cells as compared to pristine AMB. This CNT-AMB construct was able to penetrate cells rapidly within 1 h of incubation by spontaneous piercing mechanism without causing cell death. Finally, They evaluated the antifungal activity of CNTs,functionalized with AmB, against three species of fungi(Candida parapsilosis, Cryptococcus neoformans, Candida albicans). In this experiment, they used AmB that was covalently linked to ammonium functionalized multi- and single-walled carbon nanotubes (MWNT-AmB and SWNT-AmB). The functionlized forms was found to be more potent than free A MB possibly due to enhanced drug solubility and the presence of multiple copies of AMB per CNT molecule (i.e. the multivalence effect) leading to improved binding affinity between the drug and its target.177 In another separate paper by the same group, a similar MWCNTs AMB construct and a newly designed SWCNTs-AMB conjugate with PEG linker were prepared with AMB loading of 25% and 10% w/w, respectively. These conjugates were tested for their antifungal activities in comparison to pristine AMB and a conventional colloidal dispersion AMB deoxycholate formulation. Both MWCNTs-AMB construct and SWCNTs-AMB conjugate were considerably more than AMB alone. Some fugal strains which were resistant to free AMB showed a significant response to the MWCNT-based AMB conjugate.178 In another study performed by Pruthi et al., AMB was physically adsorbed on mannosylated MWCNTs inorder to treat leishmaniasis by achieving specific delivery of the drug to macrophages. the mannosylated MWCNTs had high affinity to bind lectins and were able to be uptaken by macrophages in sufficient amount. but the result of this study is unfortunately insufficient to support macrophage-targeting because a control experiment with non-mannosylated MWCNTs was not performed. Although AMB was adsorbed onto the mannosylated MWCNTs and demonstrated a sustained in vitro release profile, the use of Rh B-loaded mannosylated MWCNTs for intracellular fluorescence imaging of macrophages is inconclusive because Rh B could be detached from the MWCNTs before it enters macrophages, which means that the observed fluorescence is due to free Rh B not the MWCNTs-loaded with Rh B.179 Apart from AMB, dapsone is another example of antimicrobial that has been  successfully delivered with CNTs. It is an antimicrobial and anti-inflammatory drug that can be used to treat many diseases such as malaria, leprosy, AIDS-associated toxoplasmosis and other diseases.180 Some bacterial species developed resistance to dapsone so experiments was started to deliver dapsone with CNTs and fortunately it was delivered successfully. Dap-MWCNTs was formed by functionalizing dapsone onto oxidized MWCNTs. Dap-MWCNTs were first tested on rat peritoneal macrophages it was rapidly ingested with predominant endosomal localization without significant cytotoxicity. Dap-MWCNTs showed many advantages as it induced less apoptosis than oxidized MWCNTs and had a lower degree of oxidative stress. On the other hand, apoptosis of macrophages is important for clearance of intracellular pathogen, so the delayed apoptosis seen by Dap-MWCNTs may be counterintuitive in the treatment of infection.181 In anoter study, Pazufloxacin mesylate, an antibiotic belonging to the class of fluoroquinolones, was adsorbed onto MWCNTs functionalized with ethylenediamine. In vitro release suggested that the adsorption of pazufloxacin consists of two phases, the first one is a rapid burst release followed by a second phase of sustained release. The total amount of released pazufloxacin from the amino-functionalized CNTs was higher at pH 5.7 than pH 7.0, due to increase hydrophilicity in acidic condition. This could be advantageous in the treatment of infections, due to the acidic environment of the infected cells.182 In another hand, gentamicin, an aminoglycoside antibiotic, was incorporated into collagen hydrogel doped with 1% w/w CNTs which served as an additive to enhance the physical stability of the hydrogel and retard the release of gentamicin. The retarded release effect had took a place in the formation of irregular CNT network in the hydrogel which impeded solvent diffusion. However, The presence of CNTs can induce a simple chemical attraction between CNTs and gentamicin, and hence improve the drug loading which could affect the drug release rate.183 In addition, chloroquine is an anti-malarial drug that also possesses lysomotropic effect. Due to their ability to cause swelling and rupture of endocytic vesicles, lyosomotropic compounds have been proposed to be used as an additive to enhance gene transfection by enabling timely escape and minimizing degradation of delivered genetic material in lysosomes. For further enhancement of gene delivery with CNTs, chloroquine was loaded onto DWCNTs coated with cationic polymer PEI and plasmid encoding for luciferase. Chloroquine can be released from the CNTs in acidic condition.Coating chloroquine with cationic polymer and plasmid can strongly affect chloroquine loading. Transfection efficiency can be improved up to five folds by introduction of chloroquine compared to a non-chloroquine loaded control. Unfortunately this construct has limited uses as a biocompatible transfecting agent because it was found to have more cytotoxic effects to cells than the non-chloroquine loaded control and f ree chloroquine. In the future, this construct might prove to be effective as a treatment of intracellular malaria infection and the excellent intracellular delivery of chloroquine can explain the higher observed cytotoxicity.184 In another study, Annamalai Senthil Kumar et al. used an electrochemical route for highly selective immobilization of amoxicillin (AMX) on multiwalled carbon nanotube modified glassy carbon electrodes (GCE/[emailprotected]), without any linkers and surface functionalization. In order to reveal the immobilization of AMX both on the inner and outer (surface) walls of the carbon nanotubes. They usedX-ray diffraction, transmission electron microscopy and scanning electron microscopy. Finally, they tested its antibacterial activity against Escherichia coli, Staphylococcus aureus and Bacillus subtilis in comparison with the unmodified AMX and MWNT using disk diffusion method. They found that [emailprotected] has enhanced antibacterial activity against the three bacterial pathogens185 Liangliang Ji et al. studied the adsorption of two sulfonamide to MWCNTs. Nonporous, pure graphite was used as a comparative adsorbent The results revealed thatthe two sulfonamides have a strong adsorption to both MWNT and graphite which can be explained by( Ï€-Ï€ electron coupling)186 In another study, Xin Zhang et al, studied the adsorption of sulfamethoxazole on different carbon nanotube typesand compared the results with the adsorption to natural sorbents including soils, sediments and sludges. Many properties of carbon nanotubes contributed to the adsorption process such as surface area, diameters and surface functional groups. They showed that the adsorption coefficients of SMX on CNTs were generally twicehigher in magnitude than other natural sorbents..187 Also, Liangliang Ji et al. studied the effect of aqueous solution chemical characteristics on the tetracycline adsorption onSWNT and MWNTsuch as the effect of ionic strength (NaCl and CaCl2), the results showed that th ere is an inverse relationship between the ionic strength and the tetracycline adsorption on both SWNT and MWNT. They also studied the effect of Cu2†+ion (7.5 mg/L) that showeda higher tetracycline adsorption rate to both SWNT and MWNT due to cation bridging mechanism. They finally studied the effect of dissolved soil coal humic acids (50 mg/L) , and the results revealed that these acids have a minimal effect on SWNT while on graphite and MWNT it has a suppression effect on tetracycline adsorption.188 According to ciprofloxacin, S.A.C. Carabineiro et al. studied the adsorption capacity of ciprofloxacin on three types of carbon based materials: activated carbon, carbon nanotubes (MWCNTs) and carbon xerogel that were functionalized through oxidation with nitric acid then they were heat treated at different temperatures (between 350 and 900  °C) under a flow of N2. They demonstrated that the adsorption capacity affected inversely when the samples were treated with nitric acid. While thermal treatments, especially at 900 °C after oxidation, enhance adsorption performance.189 In another study, S. Ashok Kumar and Sea-Fue Wang studied the stabilizing of multi-walled carbon nanotubes by aqueous solution of ciprofloxacin. It was found that MWCNTs can be stabilized by ciprofloxacinand the dispersions were stable for more than a month.190 Recently, Haibo Li et al. studied the effect of PH and temperature on the adsorption of ciprofloxacin on different functionalized CNTs like: carboxyliz ed (MC), hydroxylized (MH), single-walled CNTs (SW)and graphitized multi-walled CNTs (MG).They found thatSW had the highest absorption rate for ciprofloxacin among all CNTs due to its largest surface area and they found that this is true for all PHs .Also, ciprofloxacinsorption was thermodynamically favorable For SW, while the reverse process was observed for MC and MG. For MH, ciprofloxacin sorption firstly increased then decreased with increasing temperature.191 Apart from using carbon nanotubes to deliver antimicrobial drugs, other nanmaterials were used form the same purpose. For example, Renjis T. Tom et al. prepared Ciprofloxacin-Protected Gold Nanoparticles of two different mean diameters, 4 and 20 nm. they used different analytical techniques to study the adsorption of ciprofloxacin molecule on gold nanoparticle surface. The voltammetric and spectroscopic studies confirmed that nitrogen atom of the NH moiety of piperazine group can bind strongly to Au nanoparticles. These particles are stable in dry state and at room temperature. This study showed that the release of molecule from the particles depends on the size of particles and is more in the basic medium than in pure water. These particles were found to have many application because their fluorescent nature. Finally, This study shows that metal nanoparticles could be useful carriers for ciprofloxacin and other fluoroquinolone molecules.192 Regarding to liposome, many other examples have also been developed for various applications. For ciprofloxacin, M Magallanes et al. were prepared Liposomes that incorporated ciprofloxacin by dehydration-rehydration procedure to treat Salmonella Dublin in mice sp leens. Their results revealed that a single injection of liposome-incorporated ciprofloxacin (LIC) was 10 times more effective than a single injection of free drug at preventing mortality.193 Another example conducted by MURRAY S. WEBB et al. who encapsulated ciprofloxacin into large unilamellar vesicles (LUV) and studied their antibacterial efficacy in vivo against Salmonella typhimurium in mice infected with intracellular S. typhimurium. They noticed that the LUV composed of dipalmitoylphosphatidylcholine-cholesterol (DPPC/chol), distearoylphosphatidylcholine-cholesterol (DSPC/chol), or sphingomyelin-cholesterol (SM/chol) increased the circulation lifetime of ciprofloxacin after intravenous (i.v.) administration by >15-fold. In another hand, the retention of ciprofloxacin in liposomes in the circulation decreased in the sequence SM/chol > DSPC/chol > DPPC/chol. It was noticed that after the adminsrtation of Liposomal ciprofloxacin,intravenously and intraperitoneally to mice, they conferred significant increases in the longevity of the drug in the plasma after intraperitoneal administration and in the lungs after intratracheal administration in comparison to free ciprofloxacin and the concentration of drug in the liver, spleen, lungs and kidneys is also increased. Also, they concludedthat it extended survival and reduced the number of bacteria in the liver and spleen after studying The efficacy of a single i.v. administration of an SM/chol formulation of ciprofloxacin in a Salmonella typhimurium infection mode l. The encapsulated formulation resulted in 103 to 104 fold fewer viable bacteria in the livers and spleens of infected mice than was observed for animals treated with free ciprofloxacin. These results confirmed that the utility of liposomal encapsulation of ciprofloxacin improved the pharmacokinetics, biodistribution, and antibacterial efficacy of the antibiotic.194 In another study, when negatively charged liposomes are used, ciprofloxacin efficiently inhibits the growth of M. avium in vitro in a murine macrophage-like cell line and this results also were observed in vivo by using specific stealth liposomes in a mouse model of tuberculosis infection.195 Regarding to Solid Lipid Nanoparticles (SLNs), a study conducted by D. Jain and R. Banerjee to develop single dose delivery systems based on nanotechnology for prolonged antibiotic release in a controlled manner. In this study they prepared ciprofloxacin hydrochloride-loaded nanoparticles using four different natural carrier materials: albumin, gelatin, chitosan (CS), and lipid [solid lipid nanoparticles (SLNs)] . They compared them on the basis of particle size, electro-kinetic stability, entrapment efficiency, and drug release. Their Results suggested that CS nanoparticles and SLNs were found to be promising formulations for sustained ciprofloxacin release especially for local delivery in ocular and skin infections.196 Finally, concerning to polymeric nanoparticles as nanoantibiotics to deliver ciprofloxacin, several studies were carried out. Fawaz et al. encapsulated the synthetic drug ciprofloxacin in polyisobutylcyanoacrylate (PIBCA) nanoparticles. Thay studied their pharmacokinetic after intravenous infusion to the rabbit. The results revealed that ciprofloxacin-loaded PIBCA/NP led to increased AUC, t1/2 and Vd, and to a decreased Cl as compared with free form of drug. In addition, they tested these nanoparticles against a M. avium infection in a human macrophage culture, it was found that ciprofloxacin-loaded PIBCA/NP was more effective than unbound ciprofloxacin. In spite of this, the efficacy of ciprofloxacin associated with nanoparticles was much lower than anticipated due to the cytotoxicity of the polymeric material that was observed at concentrations higher than 80 mg of PIBCA per ml.197 another study carried out by Dillen et al. to prepare Poly(lactide-co-glycolide) nanoparticles incorp orating ciprofloxacin HCl by using W/O/W emulsification solvent evaporation method. They used poly(vinylalcohol) as a stabilizer. They studied of different preparation factors on the physicochemical properties of nanoparticles. Thee microbiological activity on two types of microorganisms, Pseudomonas aeruginosa and Staphylococcus aureus, was tested. the activity against P. aeruginosa and S. aureus of the nanoparticles and aqueous solution was comparable.198 While Rosemary et al. investigated the antibacterial activity of ciprofloxacin-encapsulated silica nanoshells that were synthesized from [emailprotected] core-shell nanoparticles. In the case of Escherichia coli DH5R better antibacterial activity was showed in comparison with free ciprofloxacin, but the same activity was observed for Lactococcus lactis MG 1363. Also, nanoparticles were shown to enter the bacterial cell to exert their antibacterial effect by fluorescence imaging studies that conducted using fluorescein [emailprote cted]199 Last study carried out by Abeylath et al. where they synthesized glycosylated polyacrylate nanoparticles that had covalently-bounded three antibiotics (N-sec-butylthio b-lactam, ciprofloxacin, and a penicillin ) within their framework. The results of the microbiological test showed that the N-sec-butylthio b-lactam and ciprofloxacin nanoparticles both had powerful in vitro activities against methicillin-resistant Staphylococcus aureus and Bacillus anthracis, while the penicillin-bound nanoparticles had no antimicrobial activity

The Dropout Rate In Americas Colleges Essay -- essays research papers

The Dropout Rate in America's Colleges In 1992, the dropout rate in America's colleges was almost twenty-four percent! Therefore meaning that nearly one out of every five students that head off to college in the fall, drop out by the first semester. In addition, about one out of every three remaining students do not return for their second year. This statistic may seem outrageous, however, it is true. Furthermore, a study has shown that if the dropout rate continues at its current pace, it will reach thirty percent by the turn of the century. Although the reasons, or excuses, for dropping out are endless, the majority of dropouts can be linked to the following: home sickness, environment, and cost.   Ã‚  Ã‚  Ã‚  Ã‚  The first cause, home sickness, is not a big problem for most. However, there are many teenagers that have never been out of their state, and in few instances, out of their city. For these select few, it is extremely hard for them to leave. The first day of college can be the hardest. In particular, registering for classes. So many people are all trying to do the same thing at once. For some, this can be enough to walk to the car and go home. However, most will make it through this part of their new life. Usually the one thing that will really bother a person, is living in a small room, with at least one other person, sometimes two. Often, living with strangers will make a person uncomfortable, and wishing they were back home. This is when many will...

The Causes and Effects of Internet Addiction

What is internet addiction? * Internet Addiction: Destroying your mind. â€Å"Your Brain on Clicks† There are a lot of people today in the world, especially in the Philippines who may have been addicted to different kinds of vices. One of these may probably be called â€Å"internet addiction. † Men and women, even youngsters these days are being pulled out from their spiritual lives by the wickedness of this world and even, I myself have been greatly affected by this. Satan is attacking us slowly, that we didn’t notice what our lives may be doing, because we may usually think it is normal to be addicted to internet, but we know that God hates it. He is a jealous God. God has been hurt in many ways because when He calls us, we can’t hear because our eyes, and ears are focused on the world. In a world of rapidly advancing technology, it is hard to ignore that internet is becoming more and more centric to our lives, worldwide. Yet the convenience the electronic age provides come with a price. The ugly truth is that the internet is as addictive as it is useful. Internet addiction can destroy us in every way, and we find ourselves invariably and unwittingly chained by the shackles of the addictive elements of the internet. The early internet was used by computer experts, engineers, scientists, and librarians. There was nothing friendly about it. There were no home or office personal computers in those days, and anyone who used it, whether a computer professional or an engineer or scientist or librarian, had to learn to use a very complex system. Most people today rely on the web for almost anything. With just one click, one can find information within seconds when it would have taken hours, even days, poring through encyclopedias in the past. Social networking sites have made the world smaller, as we find friends we have lost touch with since childhood years. The Internet also provides online conveniences such as shopping, banking and paying bills. Indeed, it has also changed the way we live. However, technology comes with a price. With the advent of the internet came the proliferation of identity theft and  pornography and, lately, the emergence of also a new  disorder called  Internet Addiction Disorder (IAD), which has now become a subject of research among scientists and psychologists. Similar to gambling in our surroundings, internet addiction is also included in the  process type of addiction,  which is an addiction to certain mood behaviors. People who are internet addicts develop a compulsive habit to surf the net, join chat rooms, and nurture virtual characters by playing online games. People who are caught up in the net due to various reasons, are mostly for relaxation, work, or both. When their balance gets lost, more of their time becomes devoted in the virtual world, and then this is where the internet starts to become addictive. When a person is dysfunctioned, he or she jeopardizes or compromises his work, school, family, and relationships because of spending too much time on the net. If we lose track of time or if we neglect our responsibilities we are showing signs of a person who is extremely absorbed in the Internet. If we continue getting addicted to internet, we might risk our personal health because of excessive use. We might develop unhealthy habits like skipping our meals just to stay online, because we cannot stop the urge of using the net. Most people nowadays in our society are so addicted that whenever they cannot connect online, it brings them panic attacks or other disorders, feeling helpless and irritable. The Bible even tells us not to love the world or things in the world. Do not love the world or the things in the world. If anyone loves the world, the love of the Father is not in him. For all that is in the world—the desires of the flesh and the desires of the eyes and pride in possessions—is not from the Father but is from the world. And the world is passing away along with its desires, but whoever does the will of God abides fore ver. † (1 John 2:15-17) Because of this, as Christians and children of God, we must manage or limit internet use and control the urge to stay online longer than intended, before it becomes a serious problem for us. Recognizing this signs will help computer addicts confront and deal with their addiction and if it still goes on a person should consider getting support from friends and loved ones or seeking professional help if they suspect that they are slowly becoming addicted to the net. * What are the main causes of internet addiction? A real addiction negatively affects home life, interpersonal relationships, work, and emotional health. Often an addiction will negatively impact a person's physical health as well. * A large preoccupation with being online. Often an individual will think a lot about their last session online, and be excited about the next time they can access the Web. * An individual needs to use the Internet more frequently to get satisfaction from the activity. * Feeling bored, upset, restless, moody, depressed or anxiety-ridden when they can't be online. * Becoming angry when someone needs the computer or refusing to share time – most common in households where there are shared computers. * Forgets all about time when online. * Can't stop getting online, no matter how hard they try. * Compulsive lying  to friends and family about time spent online. Puts a job, relationship, or other responsibility at risk in order to continue to spend time online. For example, a person may cancel a date, miss a family dinner, or forget a work meeting because of their computer time. * Uses the Internet to escape frequently. In some cases the Internet may be the only activity that calms an addicted and agitated person down. * When online, or after an online session a person may feel a sense of  manic depression, guilt, anxiety, or hopelessness. * Social Causes * Some people become addicted to the Internet because of the social connections they make online. Some online relationship activity can be useful and healthy, and many people utilize forums for advice or chats for relaxation, but when a person has many close online friends and no one to count on in the real world, problems can develop. * An Internet addicted individual though, will develop highly emotional attachments to online pals or even online dates. Online relationships are attractive to some because it can feel less risky than meeting live people in person. Online friends allow people to escape their real lives and possibly fulfill their needs for emotional contacts that they don't get in real life. Some who are addicted to online relationships may even create pretend personalities or personas of themselves. This is actually a dangerous practice because often the people who create these fake lives are already low on self-esteem or desperately seeking the approval of others. Instead of seeking real help, say from a counselor, these individuals just re-make themselves online, while changing nothing about their real offline lives. This can lead to increased symptoms of depression and feelings of inadequacy. * Personality Trait Causes One  interesting paper  on Internet addiction notes that some people may be predisposed to online addictions; much like one can be predisposed to an alcohol addiction. What the paper points out is that someone with the right mix of an addictive personality, life stressors, and poor emotional health could get addicted if the Internet happens to also fall into their life during this time. * Along with the previous example are people who may become addicted because the internet reinforces a positive feeling. For example, a wife not getting her emotional needs met by her husband, may hop online and find friendly sites and people willing to talk. Each time she has an issue with her husband there are positives to getting online. This reinforces the hold the Internet can have on someone. The Effects of Internet Addiction With most teens and adolescents, there is a thin line between casual Internet use and addiction. The Internet has become a portal to knowledge and digital adventure for many, but some parents fear the negative effects of the unlimited access to all forms of content. Parents specifically take issue with the easy access their children have to explicit material, and the compulsive behavior that can stem from it. Here are the facts on Internet addiction and its effects. Read more:  The Effects of Internet Addiction | eHow. com  http://www. ehow. com/about_5247242_effects-internet-addiction. html#ixzz1gVsf1UIn Definition * According to Helpguide. org, Internet addiction can be defined as compulsive use that interferes with the natural flow of one's daily life, relationships or work. The organization also notes that Internet addiction is not yet formally identified as a psychological disorder. The concept of Internet addiction has gained popularity due to prevailing evidence that shows compulsive use can have a detrimental effect on the lifestyle and health of the individuals who are connected to it. Signs of Addiction * People who have Internet addiction tend to have mixed feelings of both joy and guilt while on the computer. They generally lose track of time and neglect responsibilities. They uncontrollably use the computer to relieve stress, cheer up or for sexual gratification. They feel anxious or irritable when away from the computer and are more likely to alienate themselves from family and friends, generally preferring to make their social connections with strangers online. Social Effect * Internet addiction can be a significant threat to one's health and social well-being in that it enforces antisocial behavior. The addiction can lead to the inability to communicate in the real world by depriving the addict of the daily practices involved with interpersonal communication. The act of using facial expressions or certain gestures to relay intended emotion or emphasize meaning decline as the addict substitutes keystrokes resembling smiley faces, or avatars. Socially, subjects become more inclined to develop personality disorders in which they identify more with their Internet representation than their real-life persona. Ultimately, an addiction to the Internet can cripple one's ability to maintain a healthy social life. Sexual Effect * There is a popular belief among promoters of Internet censorship that overexposure to the type of explicit material available online can lead to a deluded view of real-life sexual interaction and to sex addiction. Helpguide. org defines sex addiction as compulsive sexual behavior that creates negative legal, emotional, career or physical consequences. This behavior is considered a common psychological disorder stemming from Internet addiction. Addiction Candidates * People who are most susceptible to Internet addiction are teenagers, people who already have anxiety attacks or issues with anxiety, those who have undergone recent trauma that has made them home-bound and less active, people with prior addictions and those with a lack of support from their peers or family. People coping with depression are the biggest candidates to find solace in excessive computer and Internet use.

The State Of The Teaching Profession Essay - 1281 Words

The State of the Teaching Profession Before starting my debate research, I made a cluster graphic organizer to see which characteristics correlated with the topic, the state of the teaching profession. The overall themes I came up with where teacher shortage, retention, and how the implementation of the Common Core State Standards affects teacher retention. Collectively, as a group, we decided on our three debate topics: teacher residency programs, teacher shortage related to mentorship, and the Common Core State standards. In relation to teacher residencies, I am pro teacher residency programs. When I started doing more research, I noticed these programs were becoming popular and were established as a way to help with teacher retention. Teacher residences are modeled after medical residency programs. The novice teacher is given a mentor teacher and accompanies that mentor teacher for a whole year instead of one semester like the traditional programs. That being said, the National Education Association (2013) believes, â€Å"That the best way to ensure that every teacher is â€Å"profession-ready† from their first day as a teacher-of-record is for preparation programs to incorporate teacher residencies.† I must agree with the National Education Association. I feel that teacher residencies prepare teacher candidates for the reality of teaching by having a more hands on experience. Teacher candidates are being exposed to daily meetings, parent-teacher conferences, after school programs,Show MoreRelatedThe State Of The Teaching Profession Essay1304 Words   |  6 PagesThe State of the Teaching Profession Before beginning on my debate research, I made a cluster graphic organizer to see which characteristics correlated with the topic, the state of the teaching profession. The overall themes I came up with where teacher shortage, retention, and how the implementation of the common core state standards effects teachers retention. 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